The Dynamic Duo: Niche/Stem Cell Interdependency
نویسندگان
چکیده
Most tissues in our bodies undergo constant cellular turnover. This process requires a dynamic balance between cell production and elimination. Stem cells have been shown in many of these tissues to be the major source of new cells. However, despite the tremendous advances made, it still remains unclear how stem cell behavior and activity are regulated in vivo. Furthermore, we lack basic understanding for the mechanisms that coordinate niche/stem cell interactions to maintain normal tissue homeostasis. Our lab has established a novel imaging approach in live mice using the skin as a model system to investigate these fundamental processes in both physiological and pathological settings such as cancer, with the goal of understanding how tissues successfully orchestrate tissue regeneration throughout the lifetime of an organism.
منابع مشابه
A Vascular Perspective on Neurogenesis
The vasculature has been identified as a prominent feature across several stem cell niches, suggesting a crucial role in their regulation and maintenance. While a critical component of every organ and tissue, it has adopted specific features for specialized microenvironments. Most notably, the subventricular (SVZ) and subgranular (SGZ) zones of the adult brain harbor unique vascular plexi that ...
متن کاملThe Viability of Human Testis-Derived Cells on Human Serum Albumin-Based Scaffold as An Artificial Male Germ Cell Niche
Azoospermia is one of the challenging disorders affecting couples who are afflicted with infertility. Human testisderivedcells (hTCs) are suitable candidates for the initiation of in-vitro spermatogenesis for these types of patients.The current study aimed to assess the proliferation of hTCs through the cell culture on the three-dimensional (3D) porousscaffolds. Cells harveste...
متن کاملتاثیر آشیانههای جفتی شبیهسازی شده با داربست پلی لاکتیک اسید در تکثیر سلولهای بنیادی خونساز مشتق از بافت جفت انسانی
Background and Objective: Nowadays, although umbilical cord blood is a commonly used source of hematopoietic stem cell, its low frequency of these cells is the main factor limiting its clinical application. The transplantation of hematopoietic stem cells derived from placenta tissue along with umbilical cord blood cells of the same sample may be an appropriate approach to solve this problem. In...
متن کاملLive imaging reveals active infiltration of mitotic zone by its stem cell niche.
Stem cells niches are increasingly recognized as dynamic environments that play a key role in transducing signals that allow an organism to exert control on its stem cells. Live imaging of stem cell niches in their in vivo setting is thus of high interest to dissect stem cell controls. Here we report a new microfluidic design that is highly amenable to dissemination in biology laboratories that...
متن کاملA dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary.
Epithelial stem cells are maintained within niches that promote self-renewal by providing signals that specify the stem cell fate. In the Drosophila ovary, epithelial follicle stem cells (FSCs) reside in niches at the anterior tip of the tissue and support continuous growth of the ovarian follicle epithelium. Here, we demonstrate that a neighboring dynamic population of stromal cells, called es...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2015